A more complete list of publications is available.

Paczkowski Laboratory

Keegan NR, Colón Torres NJ, Stringer AM, Prager LI, Brockley MW, McManaman CL, Wade JT, Paczkowski JE. Promoter selectivity of the RhlR quorum-sensing transcription factor receptor in Pseudomonas aeruginosa is coordinated by distinct and overlapping dependencies on C4-homoserine lactone and PqsE. PLoS Genet. 2023; 19 (12): e1010900. DOI: 10.1371/journal.pgen.1010900
Pubmed Web Address
Simanek KA, Schumacher ML, Mallery CP, Shen S, Li L, Paczkowski JE. Quorum-sensing synthase mutations re-calibrate autoinducer concentrations in clinical isolates of Pseudomonas aeruginosa to enhance pathogenesis. Nat Commun. 2023; 14 (1): 7986. DOI: 10.1038/s41467-023-43702-4
Pubmed Web Address
Feathers JR, Richael EK, Simanek KA, Fromme JC, Paczkowski JE. Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation. Structure. 2022; 30 (12): 1626-1636. DOI: 10.1016/j.str.2022.10.008
Pubmed Web Address
Simanek KA, Taylor IR, Richael EK, Lasek-Nesselquist E, Bassler BL, Paczkowski JE. The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa. Microbiol Spectr. 2022; 10 (1): e0210821. DOI: 10.1128/spectrum.02108-21
Pubmed Web Address
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